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It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells
BM635 hydrochloride has an MIC50 of 0
InChi: InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H
E3 ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins
Treatment of the human haploid cell line HAP1 for 6 h with dCBP-1 reveals almost complete loss of both CBP and p300 between 10 and 1000 nM doses
TAS6417 alaxyl-M It acts to stabilize HIF-1αTAS6417 (CLN 081) is a highly effective, orally active and pan mutation selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP binding site of the EGFR hinge region, with IC50 values ranging from 1. 1 8. 0 nM. Product information CAS Number: 1661854 97 2 Molecular Weight: 396. 44 Formula: C23H20N6O Chemical Name: N [(8S) 4 amino 6 methyl 5 (quinolin 3 yl) 8H,9H pyrimido[5,4 b]indolizin 8 yl]prop 2 enamide Smiles:
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