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and efficacious inhibitor of NPM-ALK
23(7):769-81
thereby leading to accumulation of DSBs within the cells
it also has specific neurological effects
Formula: C17H8Cl3N3O2
RA190 - Ubiquitin Receptor RPN13/ADRM1 Inhibitor. CAS# 1617495-03-0 60256 and efficacious inhibitor of NPM-ALKRA190, CAS No. 1617495 03 0, is a novel potent and selective inhibitor of proteasome Ubiquitin receptor RPN13 ADRM1. It covalently binds to the cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins. Multiple myeloma (MM) lines, even those resistant to bortezomib, were sensitive to RA190 via endoplasmic reticulum stress related apoptosis.
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