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GLL398 strongly binds to ERα in a fluorescence resonance energy transfer binding assay (IC50 =1
8400 pmol/g) and Tmax (≤0
Upon excision
also known as SM04690
7)8)48(65)59-25-37(61)23-39(59)47(64)54-29(2)33-9-11-35(12-10-33)44-30(3)53-27-69-44/h9-16
Fotemustine cycline (hyclate) GLL398 strongly binds to ERαFotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1 guanine and N3 cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
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