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Formula: C23H13Cl2N3O2
which circumvents the selectivity and pharmacologic liabilities of hydroxamates
both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP
Incubation of exponentially growing RaH3 and RaH5 with 1 μM canertinib accumulated the cells in the G1-phase of the cell cycle within 24 h of treatment without induction of apoptosis
It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM)
Su-11274 - CAS# 658084-23-2 Catalog No.:M6418-10 Formula: C23H13Cl2N3O2Su 11274, CAS No. 658084 23 2, is a selective Met tyrosine kinase inhibitor with IC50 of 10 nM. Su 11274 increases tumorigenicity and enriched for melanoma initiating cells by bioenergetic modulation. Su 11274 suppresses proliferation and motility of pancreatic cancer cells. Su 11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation. Su 11274 exhibits a selective inhibition pattern toward different receptor mutated
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