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20(4):552-63
(S)-GNE-987 Catalog No.:M15817-C 20(4):552-63(S) GNE 987 (compound 4), the GNE 987 (a chimeric BET degrader) hydroxy proline epimer, abrogates binding to VHL and does not degrade BRD4 protein. (S) GNE 987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3. 9 nM) bromodomains and can be used to design PROTAC Antibody Conjugate (PAC). Product information CAS Number: 2417371 71 0 Molecular Weight: 1096. 31 Formula: C56H67F2N9O8S2 Chemical Name: (2S,4S) 1 [(2S) 2 (11 {[8 (3,5 difluoropyridin 2 yl) 4
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