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RJR-2403 hemioxalate Size:Contact [email protected] for quotation Solubility: Solubility (25°C) DMSO: 94

SKU: 1006105000

4.4
USD100.00 USD150.00

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Description

Solubility: Solubility (25°C) DMSO: 94 mg/mL(199

and antihistamine effects

by completely blocking the increase of ciliated cells and decrease of Clara cells

In syngeneic 129S1 mice

Smiles: OC(=O)C1=CC=C(C=C1C1CCCC1)C1=CNC2=NC=C(C=C12)C1C=CC=CC=1

RJR-2403 hemioxalate Size:Contact [email protected] for quotation Solubility: Solubility (25°C) DMSO: 94Metanicotine, also known as RJR 2403 and TC 2403, is a neuronal nicotinic receptor agonist, showing high selectivity for the 42 subtype. Metanicotine has high affinity to rat brain cortex (Ki = 26 + 3 nM). Metanicotine is comparable to nicotine in activating rat thalamic synaptosomes (EC50 = 732 + 155 nM and Emax = 91 + 8% for RJR 2403; EC50 = 591 + 120 nM and Emax = 100 + 25% for nicotine) . Chronic administration of RJR 2403 in combination with low

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