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Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6
PubMed PMID: 27876319
Formula: C22H47N5O21S2
Smiles: COC1=NC2=CC=C(Br)C=C2C=C1[C@@H](C1C=CC=CC=1)[C@@](O)(CCN(C)C)C1=CC=CC2=CC=CC=C21
Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker
ACS 67 r IX Shikonin is a potent TMEM16AACS 67 is an analog of latanoprost acid. Latanoprost, an F series prostaglandin (PG) analog, has been approved for use as an ocular hypotensive drug for the treatment of glaucoma clinically. Latanoprost is an isopropyl ester, a prodrug form which is converted to free latanoprost acid by endogenous esterase enzymes. In vitro: In previous study, ACS 67 was found to be able to increase the reduced glutathione levels in normotensive pigmented rabbits
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