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It has > 10 folds selectivity over the other PI-3K family kinases (IC50 0
Biological Activity:
1621175-65-2
Alzheimer's disease and polyglutamine diseases such as Spinal and Bulbar Muscular Atrophy and Huntington’s disease
(2015) Nat Commun
PF-CBP1 - CBP/p300 Bromodomain Inhibitor. CAS# 1962928-21-7 Catalog No.:M60313-10S It has > 10 foldsPF CBP1, CAS No. 1962928 21 7, is a potent and selective CBP p300 bromodomain inhibitor (IC50 ~125 nM for CBP and 363 nM for p300). It has >100 fold selectivity for CBP over BRD4, and shows selectivity over a panel of other bromodomains. PF CBP1 reduces LPS induced IL 1, IL 6 and IFN expression in macrophages in vitro. It can also downregulate RGS4 expression in primary cortical neurons in vitro. Product information CAS Number: 1962928 21 7 Molecular
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