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Smiles: CN1N=C(C=C1C1=CC=C(OCC2C=CC(Cl)=CC=2)C(=C1O)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)C(F)(F)F
5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances
whereas it is inactive in these conditions in PC3 cells at concentrations up to 10 μM
Smiles: COC1C=C(C[C@@H]2COC(=O)[C@@]2(O)CC2C=C(OC)C(O)=CC=2)C=CC=1O
Increased production of vasoconstrictive prostanoids
MAGL-IN-1 444296 Smiles: CN1N=C(C=C1C1=CC=C(OCC2C=CC(Cl)=CC=2)C(=C1O)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)C(F)(F)FMAGL IN 1 is a potent, selective, reversible and competitive inhibitor of MAGL, with an IC50 of 80 nM. MAGL IN 1 exhibits anti proliferative effects against human breast, colorectal, and ovarian cancer cells. MAGL IN 1 blocks MAGL in cell based as well as in vivo assays. Product information CAS Number: 2324160 91 8 Molecular Weight: 369. 43 Formula: C22H24FNO3 Chemical Name: 4 fluoro 3 {4 [4 (propan 2 yl)benzoyl]piperidine 1 carbonyl}phenol Smiles: