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CDK12-IN-6 (Example 174) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC50=0
noncatecholamine cardiotonic/vasodilator agent is examined in vitro in isolated guinea pig hearts
911417-87-3
EGFR (L858R)
MGAT2-IN-2 is a potent and selective acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with an IC50 of 3
PF-06424439 avoxate Hydrochloride CDK12-IN-6 (Example 174) inhibits BRCA1PF 06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM. PF 06424439 is slowly reversible, time dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl CoA substrate. Product information CAS Number: 1469284 78 3 Molecular Weight: 439. 94 Formula: C22H26ClN7O Chemical Name: (3R) 1 {2 [1 (4 chloro 1H pyrazol 1 yl)cyclopropyl] 1H imidazo[4, 5
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