Essentially, you have two options here: spend 2 generic and a black to destroy a creature, or spend exactly GWB to destroy any nonland permanent
Strefan then lets you exchange your Blood tokens for whatever powerful Vampires are lurking in your hand
Nezumi Shortfang / Stabwhisker the Odious Nezumi Shortfang has a pretty safe discard ability, but it could do some damage if you have a decent untap ability somewhere despite the mana cost
Instead of spells resolving in complete batches, players could now interact on the stack at any point, interrupts were removed from the game, combat damage used the stack, and the rules deactivating tapped artifacts and preventing tapped blockers from dealing damage were removed
That said, this seems unlikely, and if it does happen, I imagine it will be more the fault of Emrakul than anything else
There are always little tweaks you can make over time