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PP242 exhibits excellent selectivity over 215 other protein kinases
Therapeutic potential of AZD1480 for the treatment of human glioblastoma
Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1
and enables repeated photoactivation of motor behaviors in wild-type zebrafish and mice
4-dihydrophthalazin-1-yl)ethyl)benzamide
ONX-0914 - Immunoproteasome Inhibitor. CAS# 960374-59-8 size:10mg solid PP242 exhibits excellent selectivity overONX 0914, CAS No. 960374 59 8, is an immunoproteasome inhibitor. It selectively inhibits lowmolecular mass polypeptide 7 (LMP7, encoded by Psmb8), the chymotrypsin like subunit of the immunoproteasome, with an IC50 < 100 nM. It blocked presentation of LMP7 specific, MHC Irestricted antigens in vitro and in vivo with minimal cross reactivity for the constitutive proteasome. Selective inhibition of LMP7 by ONX 0914 blocked production of interleukin 23
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