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In vitro: Cytochalasin J was identified as a deacetylated analog of cytochalasin H that weakly inhibited actin assembly but significantly altered mitotic spindle microtubule organization and kinetochore structure
2 weeks) inhibits growth of syngeneic tumors by 80%
Formula: C28H48O2
Smiles: CC(C)S(=O)(=O)C1=CC=CC=C1NC1C=C(NC2=CC=C(C=C2OC)N2CCC(O)CC2)N=C2NC=CC=12
this agent is highly polyglutamylated and competes for the folate binding site of DHFR
LY 2389575 hydrochloride 17454 In vitro: Cytochalasin J wasLY2389575 is described here instead of LY2389575 hydrochloride. LY2389575 is a selective negative allosteric modulator (NAM) of metabotropic glutamate receptor 3 (mGlu3) with an IC50 value of 4. 2 M . The metabotropic glutamate receptors (mGlus) are members of the GPCR family C. They are characterized by a large extracellular amino terminal domain for binding agonist. Eight mGlus had been found and were assigned to three groups based on their
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