SB-218078 - CAS# 135897-06-2 60329 InChi: InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H

InChi: InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H

Incubation of pre-T-LBL cells with (Z)-SMI-4a induced G1 phase cell-cycle arrest secondary to a dose-dependent induction of p27(Kip1)

single-arm

Rothenfusser K

58(5):2114-34

SB-218078 - CAS# 135897-06-2 60329 InChi: InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17HSB 218078, CAS No. 135897 06 2, is a potent and selective indolocarbazole chk1 inhibitor. Product information CAS Number: 135897 06 2 Molecular Weight: 393. 39 Formula: C24H15N3O3 Chemical Name: (5R,8S) 7,8 dihydro 5H 16 oxa 4b,8a,14 triaza 5,8 methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e] as indacene 13,15(6H,14H) dione Smiles: O=C1NC(=O)C2=C1C1=C3C4=C2C2=CC=CC=C2N4C2CCC(O2)N3C2=CC=CC=C21 InChiKey: OTPNDVKVEAIXTI UHFFFAOYSA N InChi: InChI=1S