Anagliptin 1053 KW-2449 can dephosphorylate constitutively active

KW-2449 can dephosphorylate constitutively active WT-FLT3 kinase but not inhibit the proliferation of leukemia cells if they are not mainly addicted to FLT3 the kinase

In relevant biological assays

InChiKey: WOMPQPMHRDDZMP-IJBWYZRXSA-N

SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells and counteracts Cyclopamine-KAAD inhibition of Smo

2S)-1-{[(1S)-5-amino-1-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoyl-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl]carbamoyl}pentyl]carbamoyl}-2-carbamoylethyl]carbamoyl}pentyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-hydroxyethyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}pentyl]carbamoyl}pentyl]carbamoyl}ethyl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}pentyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-3-methylbutyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-carbamoylethyl]carbamoyl}-3-[(2S

Anagliptin 1053 KW-2449 can dephosphorylate constitutively activeAnagliptin is a highly selective, potent inhibitor of dipeptidyl peptidase 4 (DPP 4), with an IC50 of 3. 8 nM, and less selective at DPP 8 9 (IC50, 68, 60 nM, respectively). Product information CAS Number: 739366 20 2 Molecular Weight: 383. 45 Formula: C19H25N7O2 Chemical Name: N [2 ({2 [(2S) 2 cyanopyrrolidin 1 yl] 2 oxoethyl}amino) 2 methylpropyl] 2 methylpyrazolo[1,5 a]pyrimidine 6 carboxamide Smiles: