WH-4-023 denafil Hydrochloride Smiles: CN(CCO)C(=O)C1C=C(N[C@@H]2CCOC3=CC=CC(C)=C32)C2=NC(C)=CN2C=1

Smiles: CN(CCO)C(=O)C1C=C(N[C@@H]2CCOC3=CC=CC(C)=C32)C2=NC(C)=CN2C=1

InChiKey: JCKGSPAAPQRPBW-OAQYLSRUSA-N

Solubility: H2O : 5 mg/mL (22

it exhibits much less activity against unrelated RTKs

Salinomycin is found to have the ability to kill both cancer stem cells (CSCs) and therapy-resistant cancer cells

WH-4-023 denafil Hydrochloride Smiles: CN(CCO)C(=O)C1C=C(N[C@@H]2CCOC3=CC=CC(C)=C32)C2=NC(C)=CN2C=1WH 4 023 is a potent and selective dual Lck Src inhibitor with IC50 of 2 nM 6 nM for Lck and Src kinase respectively. The lymphocyte specific kinase ( Lck ) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and NK cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Product