GNF-2 - CAS# 778270-11-4 60153 Discovery of diverse small molecule

Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity

1396722-02-3 (deleted cas)

CAS Number: 1357389-11-7

Tumor formation and

Solubility: Solubility (25°C) DMSO: 85 mg/mL(199

GNF-2 - CAS# 778270-11-4 60153 Discovery of diverse small moleculeGNF 2, CAS No. 778270 11 4, is an allosteric inhibitor of Bcr abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr abl expressing cells. Selective for Bcr abl over a panel of serine, threonine and tyrosine kinases. Non ATP competitive. Product information CAS Number: 778270 11 4 Molecular Weight: 374. 32 Formula: C18H13F3N4O2 Chemical Name: 3 (6 {[4 (trifluoromethoxy)phenyl]amino}pyrimidin 4 yl)benzamide