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The ability of the C3 amide to fit and bind to this pocket is believed to be a key source of kinome selectivity for TyK2-IN-2 (Compoud 18)
6 hours) shows targeted downregulation of MCL-1 in both ABC and GCB subtypes
37)33(16-15-25-7-5-9-29(32)19-25)21-26-11-13-27(14-12-26)28-8-6-10-30(20-28)38(4
InChiKey: UPBQMAHYLWJGDW-UHFFFAOYSA-N
CAS Number: 1403859-14-2
PF-3450074 60276 The ability of the C3PF 3450074 (PF 74) is a specifical inhibitor of HIV 1 capsid protein (CA) and displays a broad spectrum inhibition of HIV isolates with submicromolar potency (EC50=8 640 nM). PF 3450074 (PF 74) acts at an early stage of HIV 1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors
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