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AUY-922 (50 mg/kg/week
Formulation: 10% ethanol-Solutol
Solubility: DMSO : 145 mg/mL (142
suggesting potentially a long-lasting effect of S3I-201 on tumor growth
In human umbilical vein endothelial cells (HUVECs)
ON-01910 selective p38α PROTAC AUY-922 (50 mg/kg/weekON 01910 is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo like kinase 1 inhibitor ON 01910. Na inhibits polo like kinase1 (Plk1), inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents.