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Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance
Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides
392(8):937-947
Formula: C15H18O4
a drug approved almost 30 years earlier
TS 155-2 Catalog No.:M22541-C Effects of the selective bisindolylmaleimideTS 155 2, is a macrocyclic lactone related to hygrolidin, is produced by a different Streptomyces species found in oil. It blocks thrombin evoked calcium (Ca2+) entry into cells. TS155 2 exerts hypotensive, anti platelet, anti ischaemic and anti inflammatory activity showed on the original patent, however, no literature investigation of TS155 2 is available. A rapid increase in cytosolic Ca2+ is related to the signal transduction events following the
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