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289499-45-2
Purity: ≥98% for each compound Storage: 4oC for 1 month
GSK-5959 (3a) also displays selectivity over the closely related family members
Evidence that PERK is implicated in tumorigenesis and cancer cell survival stimulated our search for small molecule inhibitors
At concentrations of 4×MIC and 8×MIC
ML-329 - CAS# 19992-50-8 Catalog No.:M6543-2 289499-45-2ML 329, CAS No. 19992 50 8, is an inhibitor of the microphthalmia associated transcription factor (MITF) pathway with an IC50 value of 1. 2 M for promoter activity of the MITF target gene TRPM 1. ML 329 showed specific activity against the MITF dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML 329 reduced the expression of multiple MITF target genes, including pigment related genes and the cell cycle regulator CDK2.