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and in vivo in monkeys and humans
CUDC-101 was IP or IV dosed to mice at 120 mg/kg once per day in the xenograft tumor model of Hep-G2
3-fold left shift of the glutamate CRC) at mGlu6 and antagonist activity (3
YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells
15(1):23-36
Enzastaurin - CAS# 170364-57-5 0280 and in vivo in monkeysEnzastaurin, CAS No. 170364 57 5, also known as DB 102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF) stimulated neo angiogenesis. This agent may decrease tumor blood supply and so tumor burden. Product information CAS Number:
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