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Bridger GJ
171179-06-9
~440 nM for JMJD2A (KDM4A) and JMJD2B (KDM4B)
Smiles: CCS(=O)C1N=C(C=C(N=1)C1=CC(=CC=C1)OCC1C=CC=CC=1)C(F)(F)F
PubMed PMID: 23370664
SCR7 - NHEJ inhibitor. CAS# 1533426-72-0 e Demethylase Bridger GJSCR7, CAS No. 1533426 72 0, is a potent and selective inhibitor of non homologous end joining (NHEJ). It inhibits joining of DSBs in cell free DNA repair system, blocks Ligase IV mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I, thereby leading to accumulation of DSBs within the cells, culminating into cytotoxicity. SCR7 inhibits NHEJ in a Ligase IV dependent manner within cells, and activates the