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Kil6425 preferentially inhibits LPA1- and LPA3-mediated responses but has only a moderate effect on LPA2
Cobalt chloride induces RhoA/ROCK activation and remodeling effect in H9c2 cardiomyoblasts: Involvement of PI3K/Akt and MAPK pathways
Formula: C27H30F3N9O
Formula: C42H22N2O10S2
1186/s12974-015-0363-z
CCG-63802 - CAS# 620112-78-9 Catalog No.:M10963-2 Kil6425 preferentially inhibits LPA1- andCCG 63802 is a potent and reversible inhibitor of RGS protein. CCG 63802 inhibits the interaction between RGS4 and Galpha(o) with an IC(50) value in the low micromolar range. CCG 63802 shows selectivity among RGS proteins with a potency order of RGS 4 > 19 = 16 > 8 >> 7. CCG 63802 inhibits the GTPase accelerating protein activity of RGS4, and thermal stability studies demonstrate binding to the RGS but not to Galpha(o). CCG 63802 represents a useful
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