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Ezekiel UR
It effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages without siginificanty inhibition on cell viability
MOA study showed P7C3 could bind nicotinamide phosphoribosyltransferase (NAMPT)
2014 Jul 1
potent and selective prostanoid EP4 receptor antagonist
SMI-4a - CAS# 438190-29-5 0256 Ezekiel URSMI 4a, CAS No. 438190 29 5, is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T cell lymphoblastic leukemia lymphoma. SMI 4a was found to induce phosphorylation of extracellular signal related kinase1 2 (ERK1 2), and the combination of SMI 4a and a mitogen activated protein kinase kinase 1 2 (MEK1 2) inhibitor was highly synergistic in killing pre T LBL cells. SMI 4a may be developed as a therapeutic
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