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Guadecitabine sodium (SGI-110 sodium) at 10mg/kg is an effective dose at reducing DNA methylation and retarding tumor growth
InChi: InChI=1S/C31H27F2N5O3S2/c1-40-13-12-34-17-20-4-8-24(36-18-20)28-16-25-30(43-28)27(10-11-35-25)41-26-9-7-22(15-23(26)33)37-31(42)38-29(39)14-19-2-5-21(32)6-3-19/h2-11
InChi: InChI=1S/C20H17F6N5O2/c21-19(22
2015 Jan 30
5 mg/mL (300
PLX5622 3 Bromide Guadecitabine sodium (SGI-110 sodium) atPLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0. 016 M; Ki=5. 9 nM). PLX5622 allows for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. Product information CAS Number: 1303420 67 8 Molecular Weight: 395. 41 Formula: C21H19F2N5O Chemical Name: 6 fluoro N [(5 fluoro 2 methoxypyridin 3 yl)methyl] 5 ({5 methyl