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Pyridone 6 interferes with JAK kinase activity by interacting within the ATP-binding cleft
Hanqing Dong
3-Dihydro-2H-benzo[d]imidazol-2-one Core
CAS Number: 1418033-25-6
2-3H3/t14-
PF-06372865 Catalog No.:M14974-2 Pyridone 6 interferes with JAKPF 06372865 is an orally active, 2 3 5 subtype selective GABAA positive allosteric modulator (PAM). PF 06372865 is a high affinity ligand at GABAA receptors containing 1 2 3 5 subunits (Kis of 2. 9 nM, 21 nM, 134 nM for 2, 1 PAM, 2 PAM, respectively), with low affinity for 4 6 subunits. PF 06372865 can across the blood brain barrier (BBB). PF 06372865 has anxiolytic activity and has the potential for epilepsy. Product information CAS Number: 1614245
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