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The majority of the cell lines tested have IC50 values below 100 nM
Brodowska K
Epub 2013 Feb 4
Formula: C20H15NO3
12(21):6547-56
YM-201636 - CAS# 371942-69-7 size:2mg solid The majority of the cellYM 201636, CAS No. 371942 69 7, is an inhibitor of retroviral budding and PIKfyve catalyzed PtdIns(3, 5)P2 synthesis, and can also halt glucose entry by insulin in adipocytes. YM 201636 almost completely inhibited basal and insulin activated 2 deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+ 4 nM for the net insulin response. Insulin induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those