The same goes for Zuko, who starts out as mono-red but ultimately becomes red-white-black (or Mardu)
You still need to actually cast the spell, which follows normal timing restrictions
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That said, I still have auctions posted for the remaining misprints and crimps that didnt sell individually
While there is the usual concern of having the creature you target removed, decks looking to utilize auras are usually accounting for that already through hexproof or similar mechanics
Brawl Legal Vintage Legal Timeless Legal Commander Legal Pauper Legal Oathbreaker Legal Penny Legal Toolbox Buy This Card Notes and Rules Information for Defiant Strike: If the target creature is an illegal target by the time Defiant Strike tries to resolve, the spell won't resolve