PS 1145 dihydrochloride 710ROTAC BRD2/BRD4 degrader-1 3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-hydroxypropanamido]-3-carboxypropanamido]propanamido]-3-methylbutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]propanoic acid

3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-hydroxypropanamido]-3-carboxypropanamido]propanamido]-3-methylbutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]propanoic acid

Formula: C24H44O2

causes a dose dependent tumour static effect that can be converted into regressions when combined with MEK1 inhibition

InChi: InChI=1S/C22H30N4O6/c1-22(2

InChi: InChI=1S/C31H38O19/c1-9(33)17(36)20(39)23(42)28-24(43)22(41)26(45)31(49-28)50-29-19(38)16-13(35)6-12(46-30-25(44)21(40)18(37)15(8-32)48-30)7-14(16)47-27(29)10-2-4-11(34)5-3-10/h2-7

PS 1145 dihydrochloride 710ROTAC BRD2/BRD4 degrader-1 3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-hydroxypropanamido]-3-carboxypropanamido]propanamido]-3-methylbutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]propanoic acidProduct information CAS Number: 1049743 58 9 Molecular Weight: 395. 67 Formula: C17H13Cl3N4O Chemical Name: (Z) N {6 chloro 9H pyrido[3,4 b]indol 8 yl}pyridine 3 carboximidic acid dihydrochloride Smiles: Cl. Cl. O C(=N\C1C=C(Cl)C=C2C=1NC1=CN=CC=C21) C1=CN=CC=C1 InChiKey: QTDCBADLGJZBHP UHFFFAOYSA N InChi: InChI=1S C17H11ClN4O. 2ClH c18 11 6 13 12 3 5 20 9 15(12)21 16(13)14(7 11)22 17(23)10 2 1 4 19 8 10;; h1 9,21H,(H,22,23); 2*1H Technical Data