A-770041 vimopan monohydrate InChi: InChI=1S/C23H27N3O2/c1-5-26(6-2)18-11-9-17(10-12-18)25-22-19-14-16(4)8-13-21(19)24-15-20(22)23(27)28-7-3/h8-15H

InChi: InChI=1S/C23H27N3O2/c1-5-26(6-2)18-11-9-17(10-12-18)25-22-19-14-16(4)8-13-21(19)24-15-20(22)23(27)28-7-3/h8-15H

LDN 212320

Sweeney ZK

ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22

It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities

A-770041 vimopan monohydrate InChi: InChI=1S/C23H27N3O2/c1-5-26(6-2)18-11-9-17(10-12-18)25-22-19-14-16(4)8-13-21(19)24-15-20(22)23(27)28-7-3/h8-15HA 770041 is a potent ans selective LCK inhibitor. Concanavalin A stimulated IL 2 production in whole blood is inhibited by A 770041 with an EC50 of approximately 80 nM. A 770041 is orally bioavailable (F = 34. 1 + 7. 2% at 10 mg kg) and has a t(1 2) of 4. 1 + 0. 1 h. Concanavalin A induced IL 2 production in vivo is inhibited by oral administration of A 770041 (in vivo EC50 = 78 + 28 nM). A 770041 reverses paclitaxel and doxorubicin resistance in