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inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis
de Oliveira AC
2014 Nov 17
JK184 was suggested to use at 1-5 µM concentration in vitro and in the cellular assays
3)13-6-4-12(5-7-13)16(22)21-17(23)20-15-10-8-14(19)9-11-15/h4-11H
Rho-Kinase-IN-1 - CAS# 1035094-83-7 227 inhibits IgE/antigen-induced vascular hyperpermeability inRho Kinase IN 1, CAS No. 1035094 83 7, is a Rho kinase (ROCK) inhibitor (Ki values of 30. 5 and 3. 9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1. 008. Product information CAS Number: 1035094 83 7 Molecular Weight: 352. 50 Formula: C20H24N4S Chemical Name: Rho Kinase IN 1 Smiles: CSC1=CC=C(CN2CC(CCC2)NC2C=C3C=NNC3=CC=2)C=C1 InChiKey: DPZSYTMLVCLGRU UHFFFAOYSA N InChi: InChI=1S C20H24N4S c1 25 19 7 4 15(5 8 19)13 24