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Heclin does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys
A 419259 also potently induces apoptosis in K-562 cells beginning at 0
When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target is inhibited >50% (PDE3
InChi: InChI=1S/C14H13N3OS/c18-13-9-5-1-2-6-10(9)16-17(13)14-15-11-7-3-4-8-12(11)19-14/h3-4
is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases
APTO-253 eptor Agonist Heclin does not block E2APTO 253 (LOR 253, LT 253) inhibits c Myc expression and selectively induces CDKN1A (p21), promotes G0 G1 cell cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO 253 is also an inducer of KLF4 (Krppel like factor 4). Product information CAS Number: 916151 99 0 Molecular Weight: 367. 38 Formula: C22H14FN5 Chemical Name: 2 (5 fluoro 2 methyl 1H indol 3 yl) 1H imidazo[4,5 f][1,10]phenanthroline Smiles:
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