Rucaparib phosphate - CAS# 459868-92-9 e (disodium pentahydrate) CC(C)[C@H](N)C(=O)OCC(CO)OCN1C=NC2C(=O)N=C(N)NC1=2

CC(C)[C@H](N)C(=O)OCC(CO)OCN1C=NC2C(=O)N=C(N)NC1=2

NS11394 has an excellent pharmacokinetic profile

and apoptosis assays

measured in a mouse B cell line (IC50=1

17(2):261-6

Rucaparib phosphate - CAS# 459868-92-9 e (disodium pentahydrate) CC(C)[C@H](N)C(=O)OCC(CO)OCN1C=NC2C(=O)N=C(N)NC1=2Rucaparib is a tricyclic indole poly(ADP Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1 mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. Product information CAS Number: 459868 92 9 Molecular Weight: 421. 36 Formula: C19H21FN3O5P Synonym: AG014699