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CAS Number: 1839519-57-1
CC1(C)C(=CC=CC=CC2=[N+](CCOCCOCCOCCOCCC(=O)ON3C(=O)CCC3=O)C3=CC=CC=C3C2(C)C)N(CCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C2=CC=CC=C12
5-tetrahydro-1H-1-benzazepin-3-yl acetate
Pharmacokinetic studies reveal that MGAT2-IN-2 displays a high plasma concentration (AUC0-8h=842 ng•h/mL) and favorable oral bioavailability (F=52%)
InChi: InChI=1S/C26H24N6O3/c1-3-32-24(28-29-30-32)20-9-6-5-8-19(20)18-14-12-17(13-15-18)16-31-23-21(25(33)34)10-7-11-22(23)27-26(31)35-4-2/h5-15H
GNE-616 emsirolimus CAS Number: 1839519-57-1GNE 616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1. 7 inhibitor (Ki of 0. 79 nM and Kd of 0. 38 nM for hNav1. 7) for the treatment of chronic pain. GNE 616 shows >1000 nM Kd and >2500 fold selectivity over hNav1. 1, hNav1. 3, hNav1. 4, and hNav1. 5. Selectivity over hNav1. 2 and hNav1. 6 is more modest at 31 and 73 fold, respectively. Product information CAS Number: 2349371 81 7 Molecular Weight: 537. 53
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