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Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
NVP-TNKS656 was used at 10 µM in vitro and cellular assays
indicating its potential for use as an anti-cancer therapy
Gossypetin (20-40 μM
107(5):686-9
BMS-986020 Catalog No.:M18191-C Targeting the CoREST complex withBMS 986020 is a high affinity and selective lysophosphatidic acid receptor 1 (LPA1) antagonist. BMS 986020 inhibits bile acid and phospholipid transporters with IC50s of 4. 8 M, 6. 2 M, and 7. 5 M for BSEP, MRP4, and MDR3, respectively. BMS 986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF). Product information CAS Number: 1257213 50 5 Molecular Weight: 482. 53 Formula: C29H26N2O5 Chemical Name: 1 {4' [3 methyl 4 ({[(1R)
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