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(1998) Bioorg Med Chem Lett
a PDGFR inhibitor
EtOH up to 100 mM
or 75 mg/kg causes tumor growth inhibition with TGI of 19%
inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects
CHIR99021 - GSK3β Inhibitor. CAS# 252917-06-9 Catalog No.:M60002-25S (1998) Bioorg Med Chem LettCHIR99021, CAS No. 252917 06 9, is the most widely used, potent and selective inhibitor of glycogen synthase kinase 3 (GSK3) with an IC50 ~7 nM. It can effectively activate Wnt signaling pathway in various cellular systems. CHIR99021 has been shown to enhance the reprogramming of murine and human somatic cells into iPSCs, potently promote expansion of embryonic stem cells and tissue specific adult stem cells (such as hematopoietic stem and progenitor
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