A UPC typically includes: 10-16 Booster Packs : Often 12-16 packs from the set or a mix of related sets, giving you 120-160 cards for chasing those chase cards
As they take damage they can end up with fewer dice, hence fewer actions to make, or if they experience horrors those dice can turn against you inflicting horrors if they land with a certain face
I think Id keep it close to my chest if it cost that much too
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Therefore, some cards wont see much play, at least until theres a shift in the meta or a highly synergistic critter or item comes along
In competitive play, you can do away with your bad hand and redraw, which boosts the chances of finding something you need