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Canertinib HCl - CAS# 289499-45-2 60273 Smiles: CC1=CC(=NN1CC1C=C(N=CC=1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1C=CC(=CC=1)OC(F)(F)F

SKU: 80847597804

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Description

Smiles: CC1=CC(=NN1CC1C=C(N=CC=1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1C=CC(=CC=1)OC(F)(F)F

HSP90 or the 53 kinases tested

As with recombinant cell systems

AR7 was shown to protect cells from oxidative stress and proteotoxicity

It increases H3K4 methylation selectively at genomic regions bound by LSD1

Canertinib HCl - CAS# 289499-45-2 60273 Smiles: CC1=CC(=NN1CC1C=C(N=CC=1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1C=CC(=CC=1)OC(F)(F)FCanertinib, also known as CI1033 and PD183805, CAS No. 289499 45 2, is a potent ErbB inhibitor for the treatment of cancer. It is an irreversible tyrosine kinase inhibitor with activity against EGFR (IC50 0. 8 nM), HER 2 (IC50 19 nM) and ErbB 4 (IC50 7 nM). By 2015, Pfizer had discontinued development of the drug. Canertinib has been reported as a substrate for OATP1B3. Interaction of canertinib with OATP1B3 may alter its hepatic disposition and can

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