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171927-40-5
(2011) Br J Cancer
InChiKey: VEWFTYOFWIXCIO-UHFFFAOYSA-N
CAS Number: 1257044-40-8
CAS Number: 1450644-28-6
PD0325901 - MEK Inhibitor. CAS#391210-10-9 60087 171927-40-5PD0325901, CAS No. 391210 10 9, is a highly potent and selective inhibitor of MEK with an IC50 of 0. 33 nM. Its potency, selectivity, and solubility are all better than many other MEK inhibitors (e. g., CI 1040). It can potently inhibit the phosphorylation and activation of MAPK ERK and tumor cell proliferation. In combination with CHIR99021, PD0325901 has been shown to promote mouse ES cell self renewal and iPSC generation. Product information CAS