(1R, 2S)-2-[(1, 3-Dihydro-1, 3-dioxo-2H-isoindol-2-yl)methyl]-N, N-diethyl-1-phenylcyclopropanecarboxamide-d10 udosteine 9-ING-41 has single-agent antitumor activity

9-ING-41 has single-agent antitumor activity in a mouse model of MCL

Formula: C25H30ClN3

1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration

InChi: InChI=1S/C17H18N2O2/c1-12(2)14-5-3-13(4-6-14)11-18-19-17(21)15-7-9-16(20)10-8-15/h3-12

1038/nature19327

(1R, 2S)-2-[(1, 3-Dihydro-1, 3-dioxo-2H-isoindol-2-yl)methyl]-N, N-diethyl-1-phenylcyclopropanecarboxamide-d10 udosteine 9-ING-41 has single-agent antitumor activityProduct information CAS Number: 1246818 55 2 Molecular Weight: 386. 51 Formula: C23H24N2O3 Chemical Name: (1R,2S) 2 [(1,3 dioxo 2,3 dihydro 1H isoindol 2 yl)methyl] N,N bis[(1,1,2,2,2 H)ethyl] 1 phenylcyclopropane 1 carboxamide Smiles: [2H]C([2H])([2H])C([2H])([2H])N(C(=O)[C@@]1(C[C@@H]1CN1C(=O)C2=CC=CC=C2C1=O)C1C=CC=CC=1)C([2H])([2H])C([2H])([2H])[2H] InChiKey: JOTWZGIFEGRKFM VVAHOJQESA N InChi: InChI=1S C23H24N2O3 c1 3 24(4 2)22(28)23(16 10 6 5 7 11