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Formula: C29H37N5O3
Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors
At 18 months
Smiles: CC1=NC=C(C=C1C1=CC(OC)=C(OC)C(=C1)OC)C1C=CC(=CC=1)N1CCNCC1
5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)-benzonitrile
BX-471 - CAS# 217645-70-0 60310 Formula: C29H37N5O3BX 471, CAS No. 217645 70 0, also known as ZK 811752, is a potent, selective non peptide CCR1 antagonist (Ki = 1 nM for human CCR1). BX 471 exhibits 250 fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. BX 471 was developed Berlex and its parent company, Schering AG. BX 471 is the lead in a series of non peptide chemokine receptor 1 (CCR1) antagonists, for the potential treatment of autoimmune diseases, in particular multiple sclerosis (MS). In