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Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1[J]
Perez-Castillo A
InChiKey: CAYJNBJPGBBDAS-WMZOPIPTSA-N
OUN10989 exhibited potent inhibition of mitosis at the G2/M stage
InChiKey: ICVKYYINQHWDLM-YOMZPPEJSA-N
LGD-3303 hoxy Naphthalene Acetic Acid Targeting therapy-resistant prostate cancer viaLGD 3303 is a selective androgen receptor modulator (SARM). LGD 3303 is a nonsteroidal, nonaromatizable androgen receptor ligand that binds to the androgen receptor with high affinity in a radiolabeled to competitive binding assay (Ki=0. 9 nM). LGD 3303 binds to the mineralocorticoid, glucocorticoid, and progesterone receptors with greatly reduces affinity in comparison with the androgen receptor (Ki=1261, 581, and 136 nM, respectively). LGD 3303
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