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Negative and positive allosteric modulators of the P2X(7) receptor
APS-2-79 modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK (mitogen-activated protein kinase kinase)
induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells
Glyparamide is a chlorophenyl-containing sulfonylurea with hypoglycemic activity
Glaucocalyxin A has antitumor effect
PF-06260933 - CAS# 1811510-56-1 719 Negative and positive allosteric modulatorsPF 06260933 is an orally active and highly selective inhibitor of MAP4K4 with IC50s of 3. 7 and 160 nM for kinase and cell, respectively. Product information CAS Number: 1811510 56 1 Molecular Weight: 296. 75 Formula: C16H13ClN4 Chemical Name: 5 (4 chlorophenyl) [3, 3' bipyridine] 6, 6' diamine Smiles: NC1=NC=C(C=C1C1C=CC(Cl)=CC=1)C1C=NC(N)=CC=1 InChiKey: KHPCIHZXOGHCLY UHFFFAOYSA N InChi: InChI=1S C16H13ClN4 c17 13 4 1 10(2 5 13)14 7 12(9 21
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