BC-LI-0186 degrader 1 Chemical Name: (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-{[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene}piperidin-2-one

Chemical Name: (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-{[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene}piperidin-2-one

InChiKey: CQSQHUPRBBCQRE-UHFFFAOYSA-N

Azido-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs

Smiles: CC1N=CSC=1C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CBr)C(C)(C)C)C=C1

Smiles: C=CC(=O)C1=CC2=CC=CC=C2C=C1

BC-LI-0186 degrader 1 Chemical Name: (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-{[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene}piperidin-2-oneBC LI 0186 is a potent and selective inhibitor of Leucyl tRNA synthetase (LRS; LeuRS) and Ras related GTP binding protein D (RagD) interaction (IC50=46. 11 nM). BC LI 0186 competitively binds to the RagD interacting site of LRS (Kd=42. 1 nM) and has on effects on LRS Vps34, LRS EPRS, RagB RagD association, mTORC1 complex formation or the activities of 12 kinases. BC LI 0186 can effectively suppress the activity of cancer associated MTOR mutants and