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Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Storage Condition: Powder: 4oC 1 year
4SC-202 was used at 10µM final concentration in various in vitro assays
Christensen JM
and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines
GV-58 60427 Generation of a Selective SmallGV 58 is a potent, selective N and P Q type Ca2+ channels agonist with EC50 of 7. 21 8. 81 uM for N type P Q type Ca2+ channel; 20 fold less potent CDK inhibitor activity. IC50 value: 7. 21 8. 81 uM (N type P Q type Ca2+ channel) Target: Ca2+ channel agonistIn comparison with the parent molecule, (R) roscovitine, GV 58 has a 20 fold less potent cyclin dependent kinase antagonist effect, a 3 to 4 fold more potent Ca2+ channel agonist effect, and 4 fold