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whereas the IC50s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK
Increasing the dose of SKF-82958 also results in a significant reduction in response rate
LY-404187 (3-10 nM) potentiates glutamate-evoked inward currents in human GluR4 transfected HEK293 cells
2019 Oct 30:1-7
SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation
Leelamine hydrochloride atadine-d9 whereas the IC50s of Y-27632Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1 regulated fatty acid lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].