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You'll have to change them for cards that are legal in the format you've selected, or else Arena will show you an Invalid Deck error

Pokemon 151 is one of the most valuable modern Pokemon TCG sets due to its celebration of the original 151 Pokemon, exclusive Japanese artwork, high pull rates for desirable cards, and massive collector demand

However, said monsters cannot be targeted by card effects nor can be destoyed

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During the Damage Step, when your DARK monster battles an opponent's monster (Quick Effect): You can send this card from your hand to the GY

They can be beneficial if the player doesn't have original production or can't afford to purchase it