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S3I-201 (NSC-74859) preferentially inhibits Stat3 DNA-binding activity over that of Stat1 (IC50 values
AC-55541activated PAR2 signaling in cellular proliferation assays
2014 Jul 18
) dose-dependently prevents disease progression in the therapeutic rat CIA model
CX-5461 was administered orally at 50 mg/kg either once daily or every 3 days
TEPP-46 (ML265) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1221186-53-3 60123 S3I-201 (NSC-74859) preferentially inhibits Stat3TEPP 46 (ML265), CAS No. 1221186 53 3, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~92 nM. It demonstrates >100 fold selectivity for PKM2 over the related PKM1, PKR, and PKL isoforms. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. TEPP 46 inhibits