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InChi: InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5
p70 S6 Kinase
9b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[3
oudemansin X has been made
pii: E1086
NVP-BEP800 Size:2mg solid InChi: InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5NVP BEP800, also known as BEP 800, is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2) terminal ATP binding pocket of Hsp90. NVP BEP800 showed activity against a panel of human tumor cell lines and primary human xenografts in vitro at nanomolar concentrations. In A375 melanoma and BT 474 breast cancer cell lines, NVP BEP800 induced client protein degradation (including ErbB2, B Raf(V600E), Raf 1, and Akt) and Hsp70
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